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PGX Report

Normal Metabolizer

Antiarrhythmic

Amiodarone | Disopyramide | Flecainide | Propafenone | Quinidine | Vernakalant |

Antihypertensive

Clonidine |

Beta blocker

Metoprolol | Propranolol |

Beta-adrenergic blocking agent

Nebivolol |

Beta-blockers

Atenolol | Bisoprolol | Carvedilol |

Anti-anginals

Ranolazine |

Beta-blocker

Sotalol |

Anticholinergic

Umeclidinium |

Prokinetic agent

Metoclopramide |

Cholinergic agonist

Cevimeline |

Anti-inflammatory

Celecoxib | Flurbiprofen |

Anti-inflammatory drug

Piroxicam |

Non steroidal anti-inflammatory drugs

Tenoxicam |

Nonsteroidal anti-inflammatory drug

Aceclofenac | Aspirin | Diclofenac | Dipyrone | Ibuprofen | Indomethacin | Lornoxicam | Lumiracoxib | Meloxicam | Nabumetone | Naproxen |

Muscle relaxants

Tolperisone |

Acetylcholinesterase inhibitor

Donepezil |

Cholinesterase inhibitor

Galantamine |

Vesicular monoamine transporter 2 (vmat2) inhibitor

Deutetrabenazine | Tetrabenazine | Valbenazine |

Selective estrogen receptor modulator

Tamoxifen |

Serotonin receptor antagonist

Ondansetron | Tropisetron |

Tyrosine kinase inhibitor

Gefitinib |

Poly (adp-ribose) polymerase (parp) inhibitor

Rucaparib |

Antinauseant/antiemetic

Palonosetron |

Alpha-adrenergic blocker

Tamsulosin |

Alpha2-adrenergic receptor agonist

Lofexidine |

Antihistamine

Meclizine |

Antimuscarinic

Darifenacin | Fesoterodine |

Selective serotonin reuptake inhibitor

Dapoxetine | Fluvoxamine | Paroxetine |

Opiod

Oxycodone |

Opioid

Codeine | Tramadol |

Antidepressant

Desvenlafaxine | Duloxetine | Fluoxetine | Nefazodone |

Antipsychotic

Aripiprazole | Brexpiprazole | Cariprazine | Clozapine | Haloperidol | Iloperidone | Paliperidone | Perphenazine | Pimozide | Quetiapine | Risperidone | Sertindole | Thioridazine | Zuclopenthixol | Aripiprazolelauroxil | Flupenthixol | Fluphenazine |

Antipsychotic

Olanzapine |

Serotonin-norepinephrine reuptake inhibitor

Venlafaxine |

Tricyclic antidepressants

Amoxapine | Desipramine | Nortriptyline | Protriptyline |

Histamine-3 (h3) receptor antagonist/inverse agonist

Pitolisant |

Serotonin modulator

Vortioxetine |

Acetylcholine receptor blocker

Tolterodine |

Beta-3 adrenergic agonists

Mirabegron |

Urate transporter inhibitor

Lesinurad |

Disease-modifying antirheumatic drug (dmard)

Upadacitinib |

Cns stimulant

Methylphenidate |

Cannabinoid

Dronabinol |

Selective serotonin receptor agonists

Eletriptan |

Beta2-agonist

Arformoterol |

Use With Caution

No Results

Use With Great Caution

Selective noradrenaline reuptake inhibitor

Drug: Atomoxetine |

Dosage Adjustment:

Children:initiate with 0.5 mg/kg dose followed by increase to 1.2 mg/kg/day after 3 days. adults:initiate with 40 mg/day dose followed by increase to 80 mg/day after 3 days.

Consider Alternative

-

Immunosuppressant

Drug: Tacrolimus |

Dosage Adjustment:

1.5 to 2 times increased standard starting dose but the dose should not exceed 0.3mg/kg/day.

Consider Alternative

-

Antimicrobials

Drug: Efavirenz |

Dosage Adjustment:

Initiate with decreased dose of 400 mg/day

Consider Alternative

-

Category 

Atomoxetine

Interpretation: Normal Metabolizer

Clinical Outcome

Use With Great Caution

Dosage Adjustment:

Children:initiate with 0.5 mg/kg dose followed by increase to 1.2 mg/kg/day after 3 days. adults:initiate with 40 mg/day dose followed by increase to 80 mg/day after 3 days.

Consider Alternative

-

Scientific Actions

Use as directed

Amiodarone

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Disopyramide

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Flecainide

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Propafenone

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Quinidine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Vernakalant

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Clonidine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Metoprolol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Propranolol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Nebivolol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Atenolol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Bisoprolol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Carvedilol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Ranolazine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Sotalol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Umeclidinium

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Metoclopramide

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Cevimeline

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Tacrolimus

Interpretation: Normal Metabolizer

Clinical Outcome

Use With Great Caution

Dosage Adjustment:

1.5 to 2 times increased standard starting dose but the dose should not exceed 0.3mg/kg/day.

Consider Alternative

-

Scientific Actions

Use as directed

Efavirenz

Interpretation: Intermediate Metabolizers

Clinical Outcome

Use With Great Caution

Dosage Adjustment:

Initiate with decreased dose of 400 mg/day

Consider Alternative

-

Scientific Actions

Use as directed

Celecoxib

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Flurbiprofen

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Piroxicam

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Tenoxicam

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Aceclofenac

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Aspirin

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Diclofenac

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Dipyrone

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Ibuprofen

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Indomethacin

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Lornoxicam

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Lumiracoxib

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Meloxicam

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose

Consider Alternative

-

Scientific Actions

Use as directed

Nabumetone

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Naproxen

Interpretation: Normal Metabolizers

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Tolperisone

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Donepezil

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Galantamine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Deutetrabenazine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Tetrabenazine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Valbenazine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Tamoxifen

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended dose(20mg/day)

Consider Alternative

-

Scientific Actions

Use as directed

Ondansetron

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initate with recommended starting dose

Consider Alternative

-

Scientific Actions

Use as directed

Tropisetron

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initate with recommended starting dose

Consider Alternative

-

Scientific Actions

Use as directed

Gefitinib

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Rucaparib

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Palonosetron

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Tamsulosin

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Lofexidine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Meclizine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Darifenacin

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Fesoterodine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Dapoxetine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Fluvoxamine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with recommended starting dose

Consider Alternative

-

Scientific Actions

Use as directed

Paroxetine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initate with recommended starting dose

Consider Alternative

-

Scientific Actions

Use as directed

Oxycodone

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Codeine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

Initiate with age and weight label recommended dosage

Consider Alternative

-

Scientific Actions

Use as directed

Tramadol

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Desvenlafaxine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Duloxetine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Fluoxetine

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer

Dosage Adjustment:

-

Consider Alternative

-

Scientific Actions

Use as directed

Nefazodone

Interpretation: Normal Metabolizer

Clinical Outcome

Normal Metabolizer