What are Chromosomes?

Learn about proteins, the molecules we’re made of.

Each Chromosome Has Many Genes

The human genome includes 21,000 or so genes, spread out along 3 billion base pairs of DNA. This DNA is distributed among 23 chromosomes, of which we have two sets. We inherit one set from each parent.

Each chromosome includes a single, linear molecule of DNA with its own set of genes. Chromosomes are numbered according to their size, and genes are arranged along them in a specific order. So a gene near the tip of the short arm of chromosome 4 in one person will be found in the same location in everyone. This means that each of our genes can be mapped to a specific place on a specific chromosome.

Genes and Much More

A gene is a segment of DNA instructions for building a particular RNA or protein molecule. Genes are very important, and they get a lot of attention. Yet they make up just 3% of our genome. Each gene is like an island separated by vast stretches of non-coding DNA—that is DNA that does not code for a product. Some of this DNA holds information about which cells should make proteins, when they should make it, and how much they should make. Other segments were left by viruses that infected our ancestors many generations ago. There is some DNA that we know is important—it is conserved between species—but we are not sure exatly why that is. Some DNA appears to have no function.

DNA in other organisms is more than just genes too, though the amount of non-coding DNA varies a lot among species. Bacteria have the smallest genomes, and around 90% of their DNA codes for RNA or protein. At the other end of the spectrum, some plants and protists have enormous genomes, with genes making up as little as 1% of the total DNA.

Chromosomes Vary in Number and Type

Humans have 23 pairs of chromosomes. The first 22 pairs are called autosomes. The last pair are called sex chromosomes, and they are different between males and females. Most females have two X chromosomes (XX), and most males have an X and a Y (XY).

Most other species have different numbers of chromosome pairs than we do. Species also vary in the number of chromosome sets they have. In some species of bees and ants, males have just one copy of every chromosome (they develop from unfertilized eggs), while females have two. Some species of plants have four or more copies of each chromosome. Bacteria have just a single chromosome, arranged in a ring.

Species also differ in how chromosomes specify sex. In birds, the sex chromosomes are called Z and W. Females are ZW and males are ZZ. The tiny roundworm C. elegans has just one type of sex chromosome called X. Those with one X chromosome (known as XO) become male, and those with two X chromosomes become hermaphrodites, meaning they make both eggs and sperm. The platypus has ten sex chromosomes. Females have five pairs of X chromosomes, and males have five X chromosomes and five Y chromosomes. Some turtles do not use sex chromosomes at all. The sex of a baby turtle depends on how warm it was during a critical period as it developed inside its egg.

Calc Sheet (numbers and types of chromosomes)

Different organisms have different numbers of chromosomes. Organisms that appear more complex do not always have more chromosomes or genes than less-complex ones.

Proteins Control Access to Genes

DNA is covered with proteins called histones. DNA wraps around the histones the way sewing thread wraps around a spool. By wrapping DNA more or less tightly, histones control which genes are active (being read to build proteins) and which genes are not.

When a cell gets ready to divide, additional histones attach to DNA, coiling it even tighter.

To learn more about how histones can help regulate access to DNA, visit The Epigenome at a Glance.

The scientific introduction

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37+ trillion cells

There are approximately over 37 trillion cells in the human body. The body relies on cell communication to replicate into healthy cells working in harmony to perform all of the basic functions necessary for human survival.

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The building blocks of life

Cells are the building blocks of all living things and provide structure to the body, nutrients from food, convert nutrients into energy, and perform specialized functions. The hereditary material is found in the cells. Cells can also make copies of themselves.

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100 trillion atoms in 1 cell

When cells are viewed granularly, we find that each of the trillions of cells in the human body is made up of 100 trillion atoms. This means that there are over 37 trillion cells multiplied by 100 trillion atoms in the human body.

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Hair contains atoms

Hair is known to carry a unique atomic signature for every human being. For this reason, it can be used as a method of identifying a person's cellular health by understanding how atoms work.

References

  • DNA is covered with proteins called histones. DNA wraps around the histones the way sewing thread wraps around a spool. By wrapping DNA more or less tightly, histones control which genes are active (being read to build proteins) and which genes are not.

  • When a cell gets ready to divide, additional histones attach to DNA, coiling it even tighter.

  • To learn more about how histones can help regulate access to DNA, visit The Epigenome at a Glance.